Patients hospitalized for acute medical illness and those undergoing surgery are at increased risk of venous thromboembolism (VTE). Obesity is an additional and independent risk factor for the risk of VTE in this population. Risk assessment models (RAMs) have been developed to help stratify the risk of VTE or bleeding events for individual patients; however, limited evidence exists on the patterns of risk and VTE prophylaxis in this population in contemporary usual clinical practice settings.
The objective of this study was to present descriptive analysis of a real-world population of admitted adult patients with acute medical illness initiating enoxaparin prophylaxis, including baseline clinical conditions event rates and risk factors for symptomatic VTE and major bleeding (MB). A separate analysis was later conducted on patients with obesity in medical and surgical inpatient settings.
Patients included in this study were identified in the Optum Market Clarity database from February 28, 2010, to June 30, 2021. Inclusion criteria included hospitalization for an acute medical illness (infection, respiratory insufficiency, inflammatory condition, cancer, heart failure, and ischemic stroke) with initiated enoxaparin prophylaxis, age ≥40 years old and 1-year continuous enrollment in the health plan. Exclusion criteria were VTE, MB or surgery within the previous 90 days, CKD stage IV and above, and ongoing treatment with anticoagulation or dual antiplatelet therapy. Event rates and risk factors for VTE and MB at 90-days were assessed.
The following conclusions were derived:
The study was conducted with top key opinion leaders in acute medical illness and hematology, and was shared at a prestigious ISTH 2023 conference as a podium presentation. A study on the obese subpopulation was presented during the poster session.
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