All Insights White Paper Unlocking Clinical Insights with Generative AI
Unlocking Clinical Insights with Generative AI
Unlocking Clinical Insights with Generative AI
Explore how LLMs deliver 100% accurate data extraction from thymoma pathology reports, streamlining workflows and accelerating clinical decision-making.

Manual abstraction of pathology reports is one of the most time-consuming and error-prone tasks in clinical data workflows. With institutions employing dozens of specialists and spending hours per patient, the need for scalable automation is urgent.
This study presents a breakthrough framework using GPT-4o to extract structured data from unstructured thymoma pathology reports, achieving 100% accuracy across five key clinical fields, without manual annotation or rigid rule engines.
What’s Inside the Study
- 100% extraction accuracy across tumor size, diagnosis type, and staging systems
- Prompt-engineered GPT-4o model that adapts to diverse report formats and terminology
- Successfully parsed handwritten notes, narrative descriptions, and synoptic summaries
- Generalizable across six hospital systems with no customization required
- Outputs aligned with CDISC-SDTM standards for seamless integration into clinical systems
Explore the full methodology, results, and future directions for deploying LLMs in clinical data workflows. Dive into the findings: complete the form now to access your copy.
FAQs
- Different tumor types may present in multiple clinically and biologically distinct forms, making standardized data capture challenging
- Differences in pathology report formats and structure across distinct hospital systems adds an additional layer of complexity to standardized data capture
- Traditional NLP methods do very well in specific applications, where terms are explicitly defined and nuances in language, grammar, and formatting don't need to be considered
- GenAI is robust to nuanced language, grammar, and formatting, built on large language models that enable execution of prompt instructions with interpretation of complex concepts
- In this experiment we extracted thymoma tumor size (with units), diagnosis type, TNM staging, and Masaoka / Masaoka-Koga staging
- Yes, we created a generalized set of prompt instructions that was robust in extracting accurate insights across pathology reports from 6 distinct hospital systems. Three of these hospital systems were used for defining / refining the prompt, while the remaining 3 were used to validate the generalizability of the prompt. Because we employed thorough validation testing, we expect the generalized prompt to do well in extracting data from pathology report formats not previously tested
- The prompt instructions can be further refined to identify and extract clinical entities in addition to the ones specified in our experiment
To demo or trial this solution, contact your Axtria Clinical Solutions team at axtria_clinicalsolutions@axtria.com

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