Intrauterine adhesions (IUAs) occur when scar tissue binds the uterine cavity surfaces, often due to surgery or infections. IUAs can lead to menstrual abnormalities, abdominal pain, infertility, recurrent abortion, and pregnancy complications, resulting in significant healthcare costs. The high recurrence rates and lack of effective treatments make IUAs a substantial clinical and economic burden. This study aimed to evaluate clinical and obstetrical outcomes in women undergoing adhesiolysis compared to those not undergoing uterine procedures, and to determine the overall disease burden regarding healthcare resource use, clinical outcomes, and costs. Key outcomes included rates of absent uterine bleeding, placenta accreta spectrum, postpartum hemorrhage, pregnancies, live births, miscarriages, pre-term deliveries, and cesarean deliveries. The observational study, conducted from before December 2019 through May 2023, involved three cohorts: women who underwent adhesiolysis, procedure-free non-IUA women, and procedure-experienced non-IUA women. Propensity score matching was used to match cohorts based on key characteristics, with clinical and economic outcomes evaluated and compared.
This report is a poster presentation of Axtria from ISPOR 2024.
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