Real-World Evidence

The Potential Of Real-World Evidence To Complement Basket Trials For Tissue-Agnostic Drugs Targeting Neurotrophic Tropomyosin-Related Kinase Gene Fusions

A basket trial is a study design in which study drug is tested simultaneously on patients with the same genetic mutation or biomarkers, regardless of the specificity of the cancer type. The goal is to identify whether the intervention drug is effective in treating the targeted genetic mutation or biomarker, rather than a specific type of cancer. This study aims to identify how alternative studies (including pooled analyses, real world studies, etc.) have been used to address the limitations of basket trials for rare patient populations treated with tissue-agnostic drugs.

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